Alleviation of OVA-Induced Airway Inflammation by Flowers of Inula japonica in a Murine Model of Asthma

Title
Alleviation of OVA-Induced Airway Inflammation by Flowers of Inula japonica in a Murine Model of Asthma
Author(s)
장현욱박영마[박영마]이윤주[이윤주]최정연[최정연]김미화[김미화]양주혜[양주혜]이응[이응]이지연[이지연]이선[이선]김극준[김극준]손종근김종연이은경[이은경]
Keywords
ALLERGIC-ASTHMA; MOUSE MODEL; CYTOKINES; EXTRACT; MODULATION
Issue Date
201105
Publisher
TAYLOR & FRANCIS LTD
Citation
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.75, no.5, pp.871 - 876
Abstract
The flowers of Inula japonica (Inulae Flos) have long been used in traditional medicine for treating inflammatory diseases. The effects on OVA-induced asthmatic mice of an Inulae Flos extract (IFE) were evaluated in this study. The anti-asthmatic effects of IFE were determined by observing eosinophil recruitment, airway hyper-responsiveness (AHR), Th2 cytokine and IgE levels, and lung histopathology. The IFE treatment effectively reduced the percentage of eosinophils and Th2 cytokines in the bronchoalveolar lavage fluid (BALF) when compared to the levels in OVA-induced mice. IFE also suppressed AHR induced by aerosolized methacholine in OVA-induced mice. The results of the histopathological studies indicate that inflammatory cell infiltration and mucus hypersecretion were both inhibited by the IFE administration when compared to the effect on OVA-induced mice. The IFE treatment also suppressed the serum IgE levels and decreased Th2 cytokines in the supernatant of cultured splenocytes. These results suggest that IFE may have therapeutic potential against asthma.
URI
http://hdl.handle.net/YU.REPOSITORY/25234http://dx.doi.org/10.1271/bbb.100787
ISSN
0916-8451
Appears in Collections:
약학대학 > 약학부 > Articles
의과대학 > 생리학교실 > Articles
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