Evaluation of comparative antidiabetic effects of ethanolic extracts of Caesalpinia bouncucella and Stevia rebaudiana in normal and alloxan-induced experimental rats

Title
Evaluation of comparative antidiabetic effects of ethanolic extracts of Caesalpinia bouncucella and Stevia rebaudiana in normal and alloxan-induced experimental rats
Author(s)
슈리티슈클라Mehta Archana[Mehta Archana]비벡바지파이
Keywords
INDUCED DIABETIC-RATS; TOTAL PHENOLIC CONTENT; ANTIOXIDANT ACTIVITY; STEVIOSIDE; PLANTS; EXPRESSION; MECHANISM
Issue Date
201105
Publisher
ARS DOCENDI
Citation
ROMANIAN BIOTECHNOLOGICAL LETTERS, v.16, no.3, pp.6187 - 6199
Abstract
In the present study, ethanolic extracts of Caesalpinia bonducella seed (ESECB) and Stevia rebaudiana leaf (ELESR) were tested separately to compare their antidiabetic effects in normal and alloxan-induced diabetic rats. To assess the anti diabetic activity, varied concentrations of the ethanolic extracts of both plants were tested in oral glucose tolerance test to determine the blood glucose levels in normal and alloxan-induced (150 mg/kg b.w) diabetic experimental rats for 21 days. The oral administration of ethanolic camels of both plants at the dosage level of 300 and 400 mg/kg body weight showed significant reduction in blood glucose levels. Comparatively, C. bonducella seed extract caused a more potent antidiabetic effect than S. rebaudiana leaf extract. Significant (p < 0.05) reduction in fasting blood glucose levels was observed in normal rats as well as in diabetic animals. Changes in body weight assessed in extracts treated diabetic rats were comparable with diabetic control and normal animals. Statistical comparison among all groups was performed by using ANOVA. Significant results were observed in the estimated parameters, thereby justifying the use of these plants in the indigenous system of phytomedicine.
URI
http://hdl.handle.net/YU.REPOSITORY/25210
ISSN
1224-5984
Appears in Collections:
중앙도서관 > rims journal
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