A multicenter study on extramammary Paget's disease in Korea

Title
A multicenter study on extramammary Paget's disease in Korea
Author(s)
신동훈이석종[이석종]최윤석[최윤석]정홍대[정홍대]안성구[안성구]차영창[차영창]조광현[조광현]최혜영[최혜영]정기양[정기양]허창훈[허창훈]김일환[김일환]김기호[김기호]김문범[김문범]김명화[김명화]김유찬[김유찬]이지범[이지범]이미우[이미우]이민걸[이민걸]이원주[이원주]신정현[신정현]서기석[서기석]원영호[원영호]
Keywords
MOHS MICROGRAPHIC SURGERY; SURGICAL-TREATMENT; PROGNOSIS; VULVA; ADENOCARCINOMA; RADIOTHERAPY; EXCISION; MAMMARY
Issue Date
201105
Publisher
WILEY-BLACKWELL
Citation
INTERNATIONAL JOURNAL OF DERMATOLOGY, v.50, no.5, pp.508 - 515
Abstract
Background There has been little research on extramammary Paget's disease (EMPD) conducted in Asia. Methods The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period. Results As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180 months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%). Conclusions In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.
URI
http://hdl.handle.net/YU.REPOSITORY/25202http://dx.doi.org/10.1111/j.1365-4632.2010.04661.x
ISSN
0011-9059
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의과대학 > 피부과학교실 > Articles
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