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dc.contributor.author장재훈ko
dc.contributor.authorHye-Ran Cha[Hye-Ran Cha]ko
dc.contributor.authorSun-Young Chang[Sun-Young Chang]ko
dc.contributor.authorHyun-Jeong Ko[Hyun-Jeong Ko]ko
dc.contributor.authorSang-Uk Seo[Sang-Uk Seo]ko
dc.contributor.authorMi-Na Kweon[Mi-Na Kweon]ko
dc.date.accessioned2015-12-17T01:25:02Z-
dc.date.available2015-12-17T01:25:02Z-
dc.date.created2015-11-13-
dc.date.issued201106-
dc.identifier.citationJOURNAL OF IMMUNOLOGY, v.186, no.12, pp.6999 - 7005-
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/25135-
dc.identifier.urihttp://dx.doi.org/10.4049/jimmunol.1003484-
dc.description.abstractAlthough the induction mechanism of secretory IgA has been well studied, that of IgG in the mucosal compartments is not well understood. In this study, vitamin A deficiency was convincingly shown to be associated with increased IgG in serum and intestinal fluid. We found increased numbers of IgG-secreting B cells in the lamina propria of the small intestine and mesenteric lymph node (MLN) of vitamin A-deficient (VAD) mice. Of note, IFN-gamma secreted by MLN dendritic cells (DCs) was significantly augmented in VAD mice, unlike control mice, and CD103(+) DCs were the main subsets to secrete IFN-gamma. The aberrant increase of IgG in VAD mice can be ascribable to IFN-gamma, because IFN-gamma(-/-) VAD mice have normal IgG levels and the addition of rIFN-gamma increased IgG production by B cells cocultured with MLN DCs from IFN-gamma(-/-) VAD mice. Oral feeding of antibiotics resulted in significant reduction of IgG in VAD mice, indicating a critical role for altered commensal bacteria for IgG class-switching recombination in the absence of vitamin A. Collectively, vitamin A deficiency provokes the generation of IFN-gamma-secreting CD103(+) DCs, which may be a critical regulator for IgG generation in the MLN. The Journal of Immunology, 2011, 186: 6999-7005.-
dc.language영어-
dc.publisherAMER ASSOC IMMUNOLOGISTS-
dc.subjectINFLAMMATORY-BOWEL-DISEASE-
dc.subjectNEONATAL FC-RECEPTOR-
dc.subjectRETINOIC ACID-
dc.subjectSMALL-INTESTINE-
dc.subjectDEFICIENT MICE-
dc.subjectLAMINA PROPRIA-
dc.subjectB-CELLS-
dc.subjectRESPONSES-
dc.subjectANTIBODIES-
dc.subjectBACTERIA-
dc.titleIFN-gamma Secreted by CD103(+) Dendritic Cells Leads to IgG Generation in the Mesenteric Lymph Node in the Absence of Vitamin A-
dc.typeArticle-
dc.identifier.wosid000291309700041-
dc.identifier.scopusid2-s2.0-79959540219-
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