Contribution of the Pedunculopontine Nucleus on Walking in Stroke Patients

Title
Contribution of the Pedunculopontine Nucleus on Walking in Stroke Patients
Author(s)
장성호여상석안상호최병연장철훈이준
Keywords
DIFFUSION TENSOR TRACTOGRAPHY; USE QUADRUPEDAL COORDINATION; DEEP BRAIN-STIMULATION; PARKINSONS-DISEASE; CORTICOSPINAL TRACT; INTERNAL CAPSULE; FUNCTIONAL MRI; SUBTHALAMIC NUCLEI; MOTOR RECOVERY; CORONA RADIATA
Issue Date
201106
Publisher
KARGER
Citation
EUROPEAN NEUROLOGY, v.65, no.6, pp.332 - 337
Abstract
Objectives: We attempted to investigate changes of the pedunculopontine nucleus (PPN) according to walking ability in chronic stroke patients, using diffusion tensor imaging (DTI). Methods: 55 consecutive chronic stroke patients who were not able to walk due to injury of the corticospinal tract (CST) at stroke onset and 22 age-matched normal control subjects were recruited. We measured the values of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the PPN and assessed the walking ability of each patient. Results: In patients who were able to walk independently, the FA value of the PPN in the affected hemisphere was increased without change of the ADC value (p<0.05). Increase of the FA value was positively correlated with the degree of walking ability (p<0.05). In contrast, the ADC value was increased in the affected hemisphere of patients who could not walk, without change of the FA value (p<0.05). This increase of the ADC value was negatively correlated with the degree of walking ability (p<0.05). Conclusion: We found that the neuronal activity of the PPN in the affected hemisphere was increased in stroke patients who were able to walk independently. Therefore, we think that the PPN in the affected hemisphere contributed to walking ability in stroke patients with CST injury. Copyright (C) 2011 S. Karger AG, Basel
URI
http://hdl.handle.net/YU.REPOSITORY/25120http://dx.doi.org/10.1159/000324152
ISSN
0014-3022
Appears in Collections:
의과대학 > 재활의학교실 > Articles
의과대학 > 신경외과학교실 > Articles
의과대학 > 신경과학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE