Recent Advances in the Studies on Luotonins

Title
Recent Advances in the Studies on Luotonins
Author(s)
장영동량경록차효창
Keywords
TOPOISOMERASE-I POISON; QUINAZOLINE-QUINOLINE ALKALOIDS; EFFICIENT TOTAL-SYNTHESIS; DIELS-ALDER REACTION; ONE-POT SYNTHESIS; PEGANUM-NIGELLASTRUM; RADICAL CYCLIZATION; ANTITUMOR AGENTS; FACILE SYNTHESIS; IMINYL RADICALS
Issue Date
201106
Publisher
MDPI AG
Citation
MOLECULES, v.16, no.6, pp.4861 - 4883
Abstract
Luotonins are alkaloids from the aerial parts of Peganum nigellastrum Bunge. that display three major skeleton types. Luotonins A, B, and E are pyrroloquinazolinoquinoline alkaloids, luotonins C and D are canthin-6-one alkaloids, and luotonin F is a 4(3H)-quinazolinone alkaloid. All six luotonins have shown promising cytotoxicities towards selected human cancer cell lines, especially against leukemia P-388 cells. Luotonin A is the most active one, with its activity stemming from topoisomerase I-dependent DNA-cleavage. Such intriguing biological activities and unique structures have led not only to the development of synthetic methods for the efficient synthesis of these compounds, but also to interest in structural modifications for improving the biological properties. Recent progress in the study of luotonins is covered.
URI
http://hdl.handle.net/YU.REPOSITORY/25113http://dx.doi.org/10.3390/molecules16064861
ISSN
1420-3049
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약학대학 > 약학부 > Articles
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