3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: Synthesis, characterization and anti-microbial activity

Title
3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: Synthesis, characterization and anti-microbial activity
Author(s)
최인호압둘루프바트Tazeem[Tazeem]Amir Azam[Amir Azam]Fareeda Athar[Fareeda Athar]
Keywords
ANTITUBERCULOSIS ACTIVITY; STREPTOCOCCUS-PNEUMONIAE; STAPHYLOCOCCUS-AUREUS; RESISTANCE; AGENTS; THIADIAZOLE; INHIBITORS; THERAPY; POTENT
Issue Date
201106
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.46, no.7, pp.3158 - 3166
Abstract
A new series of thiadiazoles and intermediate thiosemicarbazones were synthesized from the chloroquinone molecule, with an aim to explore their effect on in vitro growth of microorganisms causing microbial infection. The chemical structures of the compound were elucidated by elemental analysis, FTIR, 1H and 13C NMR and ESI-MS spectral data. In vitro anti-microbial activity was performed against Staphylococcus aureus, Streptococcus pyogenes, Salmonella typhimurium, and Escherichia coli. The MIC was detected using the double dilution method. The results were compared by calculating percent inhibit area/mu g of the compounds and the standard "amoxicillin". The selected compounds were tested for cytotoxic results using MIT assay H9c2 cardiac myoblasts cell line and the results showed that all the compounds offered remarkable >80% viability to a concentration of 200 mu g/mL. (C) 2011 Elsevier Masson SAS. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/25095http://dx.doi.org/10.1016/j.ejmech.2011.04.013
ISSN
0223-5234
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생명공학부 > 생명공학부 > Articles
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