Amperometric proton selective strip-sensors with a microelliptic liquid/gel interface for organophosphate neurotoxins

Title
Amperometric proton selective strip-sensors with a microelliptic liquid/gel interface for organophosphate neurotoxins
Author(s)
김창섭Md. Mokarrom Hossain[Md. Mokarrom Hossain]Shaikh Nayeem Faisal[ Shaikh Nayeem Faisal]차형준[차형준]남상철[남상철]이혜진[이혜진]
Keywords
NERVE AGENTS; BIOSENSOR; ELECTRODE; PESTICIDES; HYDROLASE; PH
Issue Date
201106
Publisher
ELSEVIER SCIENCE INC
Citation
ELECTROCHEMISTRY COMMUNICATIONS, v.13, no.6, pp.611 - 614
Abstract
A novel strip-based disposable amperometric proton sensor that can selectively detect organophosphate neurotoxins (i.e., paraoxon) is described. The detection methodology is based on measuring the current change involved in the assisted proton transfer by a proton selective ligand (e.g., ETH 1778) across a microelliptic hole interface between the aqueous and polyvinylchloride-2-nitrophenyloctylether gel phase. The selective detection of paraoxon is achieved by measuring protons released by the specific hydrolysis of paraoxon with the organophosphorus hydrolase enzyme. A two-step process involving the hydrolysis and proton transfer reaction was characterized using cyclic voltammetry and differential pulse stripping voltammetry. A strip-based sensor fabricated using a simple polydimethylsiloxane (PDMS) mold with the resulting device was found to exhibit a linear response over a wide range of paraoxon concentrations (0.5 mu M-100 mu M) present in aqueous samples. In addition to the excellent detection limit and a wide dynamic range, a superb selectivity in the presence of common interfering agents in agricultural samples is achieved. (C) 2011 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/25093http://dx.doi.org/10.1016/j.elecom.2011.03.024
ISSN
1388-2481
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이과대학 > 화학생화학부 > Articles
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