Neuroprotective effect of forsythiaside against transient cerebral global ischemia in gerbil

Title
Neuroprotective effect of forsythiaside against transient cerebral global ischemia in gerbil
Author(s)
이승호김종민[김종민]김선호[김선호]이종호[이종호]박세진[박세진]고광호[고광호]정재훈[정재훈]류종훈[류종훈]김동현[김동현]정지욱[정지욱]
Keywords
DELAYED NEURONAL DEATH; FIBRILLARY ACIDIC PROTEIN; INDUCED MEMORY IMPAIRMENT; TUMOR-NECROSIS-FACTOR; BRAIN-DAMAGE; RAT-BRAIN; PROINFLAMMATORY CYTOKINES; MICROGLIAL ACTIVATION; FOREBRAIN ISCHEMIA; OXIDATIVE STRESS
Issue Date
201106
Publisher
ELSEVIER SCIENCE BV
Citation
EUROPEAN JOURNAL OF PHARMACOLOGY, v.660, no.2-3, pp.326 - 333
Abstract
Forsythiaside, a phenylethanoside, has been reported to have anti-oxidative activity and memory ameliorating effects against a scopolamine-induced memory deficit model. The aim of this study was to determine whether forsythiaside has neuroprotective activity on transient cerebral global ischemia in gerbil. Transient cerebral ischemia was induced by bilateral common carotid artery occlusion for 5 mm and followed by reperfusion for 7 days. Oral administration of forsythiaside was conducted immediately after reperfusion and once a day over the next 7 days. The forsythiaside administration significantly increased the number of viable neurons detected by neuronal nuclei immunostaining and decreased degenerating neuronal cells detected by Fluoro-Jade B staining in the hippocampal CA1 region, at the 7th day post-ischemia (P<0.05). Forsythiaside also significantly decreased the number of ionized calcium-binding adaptor molecule-l-detected activated microglia and glial fibrillary acidic protein-detected astrocytes, both of which were increased after ischemic insults, and decreased interleukin-1 beta and tumor necrosis factor-alpha expression levels, which were also increased after the insults (P<0.05). In addition, forsythiaside significantly improved ischemia-induced cognitive impairments in the Y-maze task (P<0.05). These results suggest that forsythiaside exhibits neuroprotective properties, which are, in part, mediated by its anti-inflammatory activities supported by forsythiaside-induced reductions of activated glial cells and expression levels of interleukin-1 beta and tumor necrosis factor-alpha. (C) 2011 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/25088http://dx.doi.org/10.1016/j.ejphar.2011.03.051
ISSN
0014-2999
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약학대학 > 약학부 > Articles
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