Involvement of IGF binding protein 5 in prostaglandin E-2-induced cellular senescence in human fibroblasts

Title
Involvement of IGF binding protein 5 in prostaglandin E-2-induced cellular senescence in human fibroblasts
Author(s)
김재룡양효현김찬석[김찬석]정보찬[정보찬]김광석[김광석]
Keywords
HUMAN-DIPLOID FIBROBLASTS; HUMAN DERMAL FIBROBLASTS; REPLICATIVE SENESCENCE; LYSOPHOSPHATIDIC ACID; PHOSPHOLIPASE A(2); GENE-EXPRESSION; EP2 RECEPTOR; GROWTH; CELLS; PROLIFERATION
Issue Date
201106
Publisher
SPRINGER
Citation
BIOGERONTOLOGY, v.12, no.3, pp.239 - 252
Abstract
Inflammation is an underlying basis for the molecular alterations that link aging and age-related pathological processes. In a previous study, we found that secretory phospholipase A(2) (sPLA(2)) induced cellular senescence in human dermal fibroblasts (HDFs). To further investigate the association of inflammation with cellular senescence, the effects of PGE(2) on cellular senescence in HDFs were investigated, since PGE(2) is the most abundant prostanoid. PGE(2) treatment induces cellular senescence, as determined by a decrease in cell proliferation and an increase in senescence-associated beta-galactosidase staining. Notably, PGE(2) treatment increased the IGFBP5 protein level. While treatment with PGE(2) antagonists repressed PGE(2)-induced cellular senescence, increasing intracellular cAMP accelerated cellular senescence. Down-regulation of IGFBP5 inhibited PGE(2)-induced cellular senescence. Taken together, these results suggest that PGE(2) may play an important role in controlling cellular senescence of HDFs through the regulation of IGFBP5 and therefore may contribute to inflammatory disorders associated with aging.
URI
http://hdl.handle.net/YU.REPOSITORY/25087http://dx.doi.org/10.1007/s10522-010-9318-z
ISSN
1389-5729
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
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