Clinical Characteristics of Microscopic Colitis in Korea: Prospective Multicenter Study by KASID

Title
Clinical Characteristics of Microscopic Colitis in Korea: Prospective Multicenter Study by KASID
Author(s)
장병익박영숙[박영숙]백대현[백대현]김원호[김원호]김주성[김주성]양석균[양석균]정성애[정성애]최창환[최창환]한동수[한동수]김영호[김영호]정용우[정용우]김상우[김상우]김유선[김유선]
Keywords
COLLAGENOUS-COLITIS; CHRONIC DIARRHEA; LYMPHOCYTIC COLITIS; SWEDEN; OREBRO
Issue Date
201106
Publisher
EDITORIAL OFFICE GUT & LIVER
Citation
GUT AND LIVER, v.5, no.2, pp.181 - 186
Abstract
Background/Aims: Microscopic colitis (MC) encompasses collagenous and lymphocytic colitis and is characterized by chronic diarrhea. In cases of MC, colonic mucosae are macroscopically normal, and diagnostic histopathological features are observed only upon microscopic examination. We designed a prospective multicenter study to determine the clinical features, pathological distribution in the colon and prevalence of MC in Korea. Methods: We prospectively enrolled patients having watery diarrhea no more than 3 times a day between March 2008 and February 2009. We obtained patient histories and performed colonoscopies with random biopsies at each colon segment. Results: A total of 100 patients with chronic diarrhea were enrolled for a normal colonoscopy and stool exam. MC was observed in 22 patients (22%) (M:F 1.2:1; mean age, 47.5 years). Of those 22 patients, 18 had lymphocytic colitis and 4 had collagenous colitis. The entire colon was affected in only 3 cases (13.6%), the ascending colon in 6 cases (27.2%), the transverse colon in 3 cases (13.6%), and the left colon in 3 cases (13.6%). More than 2 segments were affected in 7 cases (31.8%). Nonsteroidal anti-inflammatory drug-associated MCs were observed in 4 cases (18.2%), 3 of which showed improved diarrhea symptoms following discontinuation of the medication. Frequently associated symptoms were abdominal pain and weight loss. Autoimmune diseases were observed in 4 cases (18.2%). Half of the 22 patients with MC improved with conservative care by loperamide or probiotics. Conclusions: In a prospective multicenter study of Korean patients with chronic diarrhea, the frequency of MC was found to be approximately 20%, similar to the percentage observed in Western countries. Therefore, the identification of MC is important for the adequate management of Korean patients with chronic diarrhea. (Gut Liver 20115:181-186)
URI
http://hdl.handle.net/YU.REPOSITORY/25080http://dx.doi.org/10.5009/gnl.2011.5.2.181
ISSN
1976-2283
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의과대학 > 내과학교실 > Articles
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