Determination of Malignant and Invasive Predictors in Branch Duct Type Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Suggested Scoring Formula

Title
Determination of Malignant and Invasive Predictors in Branch Duct Type Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Suggested Scoring Formula
Author(s)
이동식Dae Wook Hwang[Dae Wook Hwang]Jin-Young Jang[Jin-Young Jang]Chang-Sup Lim[Chang-Sup Lim]Seung Eun Lee[Seung Eun Lee]Yoo-Seik Yoon[Yoo-Seik Yoon]Young Joon Yun[Young Joon Yun]SUn-Whe Kim[SUn-Whe Kim]Sang Seol Kim[Sang Seol Kim]Young Kook Yun[Young Kook Yun]Seong-Sik Han[Seong-Sik Han]Sang-Jae Park[Sang-Jae Park]Tae Jin Lim[Tae Jin Lim]Koo Jung Kang[Koo Jung Kang]Mun Sup Sim[Mun Sup Sim]Seong Ho Choi[Seong Ho Choi]Jin Seok Heo[Jin Seok Heo]Dong-Wook Choi[Dong-Wook Choi]Kyung Yul Hur[Kyung Yul Hur]윤성수김홍진Chul Kyoon Cho[Chul Kyoon Cho]Hyun Jong Kim[Hyun Jong Kim]Hee chul Yu[Hee chul Yu]Baik Hwan Cho[Baik Hwan Cho]In-Sang Song[In-Sang Song]
Keywords
CLINICOPATHOLOGICAL FEATURES; HEAD RESECTION; MANAGEMENT; TUMORS; CT; CLASSIFICATION; GUIDELINES; EXPERIENCE; DIAGNOSIS; OPERATE
Issue Date
201106
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.26, no.6, pp.740 - 746
Abstract
Prediction of malignancy or invasiveness of branch duct type intraductal papillary mucinous neoplasm (Br-IPMN) is difficult, and proper treatment strategy has not been well established. The authors investigated the characteristics of Br-IPMN and explored its malignancy or invasiveness predicting factors to suggest a scoring formula for predicting pathologic results. From 1994 to 2008, 237 patients who were diagnosed as Br-IPMN at 11 tertiary referral centers in Korea were retrospectively reviewed. The patients' mean age was 63.1 +/- 9.2 yr. One hundred ninty-eight (83.5%) patients had nonmalignant IPMN (81 adenoma, 117 borderline atypia), and 39 (16.5%) had malignant IPMN (13 carcinoma in situ, 26 invasive carcinoma). Cyst size and mural nodule were malignancy determining factors by multivariate analysis. Elevated CEA, cyst size and mural nodule were factors determining invasiveness by multivariate analysis. Using the regression coefficient for significant predictors on multivariate analysis, we constructed a malignancy-predicting scoring formula: 22.4 (mural nodule [0 or 1]) + 0.5 (cyst size [mm]). In invasive IPMN, the formula was expressed as invasiveness-predicting score = 36.6 (mural nodule [0 or 1]) + 32.2 (elevated serum CEA [0 or 1]) + 0.6 (cyst size [mm]). Here we present a scoring formula for prediction of malignancy or invasiveness of Br-IPMN which can be used to determine a proper treatment strategy.
URI
http://hdl.handle.net/YU.REPOSITORY/25076http://dx.doi.org/10.3346/jkms.2011.26.6.740
ISSN
1011-8934
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의과대학 > 성형외과학교실 > Articles
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