Anti-Inflammatory Activity of Compounds from the Whole Plant of Patrinia saniculaefolia

Title
Anti-Inflammatory Activity of Compounds from the Whole Plant of Patrinia saniculaefolia
Author(s)
Ren-Bo An[Ren-Bo An]나민균민병선[민병선]장현욱배기환[배기환]
Keywords
Patrinia saniculaefolia; Valerianaceae; Cyclooxygenase-2; 5-Lipoxygenase; Anti-inflammatory activity
Issue Date
201106
Publisher
한국생약학회
Citation
Natural Product Sciences, v.17, no.2, pp.90 - 94
Abstract
An in vitro bioassay-guide revealed that the methanol (MeOH) extract of the whole plant of Patrinia saniculaefolia (Valerianaceae) showed cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) dual inhibitory activity by assessing their effects on the production of prostaglandin D2 (PGD2) and leukotriene C4 (LTC4) in mouse bone marrow-derived mast cells (BMMCs). Phytochemical study of the MeOH extract of this plant led to the isolation of twelve compounds; b-farnesene (1), squalene (2), nardostachin (3), patridoid I (4), patridoid II (5), patridoid II-A (6), oleanolic acid (7), oleanonic acid (8), 23-hydroxyursolic acid (9), oleanolic acid 3-O-a-L-arabinopyranoside (10), oleanolic acid 3-O-b-D-glucopyranoside (11), oleanolic acid 3-O-[b-D-xylopyranosyl-(1 → 3)-b-D-(6-O-butyl)glucuronopyranoside] (12). Among the compounds, 4 and 5 strongly inhibited both the COX-2-dependent PGD2 generation with IC50 values of 8.7 and 13.6 mM, respectively, and the generation of LTC4 in the 5-LOX dependent phase with IC50 values of 41.7 and 46.9 mM, respectively, which suggest that the anti-inflammatory activity of P. saniculaefolia might occur in part via the inhibition of both PGD2 and LTC4 generation by 4 and 5.
URI
http://hdl.handle.net/YU.REPOSITORY/25040
ISSN
1226-3907
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약학대학 > 약학부 > Articles
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