Cytotoxicity of Ergosterol Derivatives from the Fruiting Bodies of Hygrophorus russula

Title
Cytotoxicity of Ergosterol Derivatives from the Fruiting Bodies of Hygrophorus russula
Author(s)
이익수[이익수]김진표[김진표]나민균정현주[정현주]민병선[민병선]배기환[배기환]
Keywords
Hygrophorus russula; Hygrophoraceae; Ergosterol derivatives; Cytotoxicity
Issue Date
201106
Publisher
한국생약학회
Citation
Natural Product Sciences, v.17, no.2, pp.85 - 89
Abstract
Bioassay-guided fractionation of the CHCl3-soluble fraction of a MeOH extract of the fruiting bodies of Hygrophorus russula led to the isolation of five ergosterol derivatives (1 - 5). The structures of these compounds were identified as ergosterol peroxide (1), ergosta-4,6,8(14),22-tetraen-3-one (2), ergosta-7,22-diene-3b,5a,6a-triol (3), ergosta-7,22-diene-3b,5a,6b,9a-tetraol (4), and 5a,6a-epoxy-ergosta-8(14),22-diene-3b,7a-diol (5) by comparing their physicochemical and spectral data with those in the literature. These compounds were evaluated for in vitro cytotoxicity against A549 and XF498 cancer cell lines. Most of the tested compounds, except for compound 3, exhibited moderate cytotoxicity against both A549 and XF498 cell lines with IC50 values ranging from 10.2 to 18.3 ?g/mL and from 11.4 to 24.6 ?g/mL, respectively.
URI
http://hdl.handle.net/YU.REPOSITORY/24989
ISSN
1226-3907
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약학대학 > 약학부 > Articles
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