A Cytotoxic Monoterpene-Neolignan from the Stem Bark of Magnolia officinalis

Title
A Cytotoxic Monoterpene-Neolignan from the Stem Bark of Magnolia officinalis
Author(s)
윤의중[윤의중]이익수[이익수]Quan Cheng Chen[Quan Cheng Chen]나민균정현주[정현주]이상명[이상명]최재수[최재수]우미희[우미희]배기환[배기환]민병선[민병선]
Keywords
Magnolia officinalis; Magnoliaceae; Monoterpene-neolignan; Cytotoxic activity
Issue Date
201106
Publisher
한국생약학회
Citation
Natural Product Sciences, v.17, no.2, pp.95 - 99
Abstract
A monoterpene-neolignan, piperitylmagnolol (1), was isolated from the stem bark of Magnolia officinalis, together with syringaresinol (2), caffeic acid (3), and sinapaldehyde (4). The isolated compounds were established on the basis of spectroscopic and physicochemical analyses including 1D- and 2D- NMR techniques, as well as on comparing the spectral data with those in the literature and of authentic samples. Compounds 1 - 4 were tested for their cytotoxic activity against the HeLa, K562, A549, and HCT116 cancer cell lines in vitro. Of the isolates, piperitylmagnolol (1) exhibited cytotoxic activity against the tested cancer cell lines with IC50 values of 7.7 - 9.5 mg/mL.
URI
http://hdl.handle.net/YU.REPOSITORY/24958
ISSN
1226-3907
Appears in Collections:
약학대학 > 약학부 > Articles
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