홍화의 성분 분리 및 항산화 활성

Title
홍화의 성분 분리 및 항산화 활성
Other Titles
Constituents of Flowers of Carthamus tinctorius L. and Their Antioxidant Activity
Author(s)
이승호최현규강연복박성희[박성희]손애량[손애량]나민균
Keywords
Carthamus tinctorius; DPPH; Quercertin-3-O-β-D-glucopyranoside; Acetylenic glycoside
Issue Date
201106
Publisher
한국생약학회
Citation
생약학회지, v.42, no.2, pp.110 - 116
Abstract
As part of our ongoing study focused on the discovery of antioxidants from natural products by measuring the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity, methanol extract of flowers of Carthamustinctorius L. was found to show potent antioxidant activity. Activity-guided fractionation of the methanol extract lead to the isolation of twenty compounds including two flavonol glycosides, quercertin-3-O-β-D-glucopyranoside (12) and kaempferol 3-O-α-L-rhamnopyranosyl-β-D-glucopyranoside (18), two flavanone glycosides, (2S)-4',5,6,7-tetrahydroxyflavanone 6-O-β-D-glucopyranoside (15) and (2R)-5,7,8',4-tetrahydroxyflavanone 8-O-β-D-glucopyranoside (16), and two acetylenic glycosides, 8Z-decaene-4,6-diyne-1-O-β-D-glucopyranoside (13) and 4,6-decadiyne-1-O-β-D-glucopyranoside (14). Their chemical structures were identified by using spectroscopic analysis. Among them, compounds 12-18 were tested in DPPH assay. Compounds 13-16 were first reported to their antioxidant activity. Quercertin-3-O-β-D-glucopyranoside (12) showed the most potent inhibitory effect on DPPH with IC_50 value of 56.7 μM.
URI
http://hdl.handle.net/YU.REPOSITORY/24951
ISSN
0253-3073
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약학대학 > 약학부 > Articles
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