Cytotoxic Activity of Parthenin, a Sesquiterpene Isolated from a Crinum ensifolium

Title
Cytotoxic Activity of Parthenin, a Sesquiterpene Isolated from a Crinum ensifolium
Author(s)
Nguyen Minh Khoi[Nguyen Minh Khoi]Nguyen Tien Dat[Nguyen Tien Dat]나민균Phuong Thien Thuong[Phuong Thien Thuong]민병선[민병선]배기환[배기환]
Keywords
Crinum ensifolium; Amaryllidaceae; parthenin; cytotoxic activity; NF-kB inhibition
Issue Date
201106
Publisher
한국생약학회
Citation
Natural Product Sciences, v.17, no.2, pp.100 - 103
Abstract
Phytochemical study on the ethanol extract of a Crinum species by bioassay-guided fractionation resulted in the isolation of an active principle, which was determined as parthenin (1) on the basis of physicochemical and spectroscopic analyses. This is the first report on the existence of a sesquiterpenoid from Crinum ensifolium. Compound 1 was found to show strong cytotoxic activity against some cancer cell lines and strongly inhibit NF-kB activity with the IC50 value of 1.82 mM.
URI
http://hdl.handle.net/YU.REPOSITORY/24927
ISSN
1226-3907
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE