Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL)

Title
Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL)
Author(s)
김석진[김석진]김원석[김원석]김민경최철원[최철원]문영철[문영철]오성용[오성용]강혜진[강혜진]이순일[이순일]원종호[원종호]김진석[김진석]곽재용[곽재용]권정미[권정미]황인규[황인규]권정혜[권정혜]김효정[김효정]이재훈[이재훈]오석중[오석중]박건우[박건우]서철원[서철원]
Keywords
INTERNATIONAL PROGNOSTIC INDEX; B-CELL LYMPHOMA; GIT NHL 01/92/; CLINICAL-FEATURES; GASTROINTESTINAL LYMPHOMA; GERMAN MULTICENTER; CLINICOPATHOLOGICAL ANALYSIS; MALIGNANT-LYMPHOMAS; GASTRIC-LYMPHOMA; TRACT LYMPHOMA
Issue Date
201107
Publisher
BIOMED CENTRAL LTD
Citation
BMC CANCER, v.11
Abstract
Background: Primary intestinal non-Hodgkin lymphoma (NHL) is a heterogeneous disease with regard to anatomic and histologic distribution. Thus, analyses focusing on primary intestinal NHL with large number of patients are warranted. Methods: We retrospectively analyzed 581 patients from 16 hospitals in Korea for primary intestinal NHL in this retrospective analysis. We compared clinical features and treatment outcomes according to the anatomic site of involvement and histologic subtypes. Results: B-cell lymphoma (n = 504, 86.7%) was more frequent than T-cell lymphoma (n = 77, 13.3%). Diffuse large B-cell lymphoma (DLBCL) was the most common subtype (n = 386, 66.4%), and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) was the second most common subtype (n = 61, 10.5%). B-cell lymphoma mainly presented as localized disease (Lugano stage I/II) while T-cell lymphomas involved multiple intestinal sites. Thus, T-cell lymphoma had more unfavourable characteristics such as advanced stage at diagnosis, and the 5-year overall survival (OS) rate was significantly lower than B-cell lymphoma (28% versus 71%, P < 0.001). B symptoms were relatively uncommon (20.7%), and bone marrow invasion was a rare event (7.4%). The ileocecal region was the most commonly involved site (39.8%), followed by the small (27.9%) and large intestines (21.5%). Patients underwent surgery showed better OS than patients did not (5-year OS rate 77% versus 57%, P < 0.001). However, this beneficial effect of surgery was only statistically significant in patients with B-cell lymphomas (P < 0.001) not in T-cell lymphomas (P = 0.460). The comparison of survival based on the anatomic site of involvement showed that ileocecal regions had a better 5-year overall survival rate (72%) than other sites in consistent with that ileocecal region had higher proportion of patients with DLBCL who underwent surgery. Age > 60 years, performance status >= 2, elevated serum lactate dehydrogenase, Lugano stage IV, presence of B symptoms, and T-cell phenotype were independent prognostic factors for survival. Conclusions: The survival of patients with ileocecal region involvement was better than that of patients with involvement at other sites, which might be related to histologic distribution, the proportion of tumor stage, and need for surgical resection.
URI
http://hdl.handle.net/YU.REPOSITORY/24912http://dx.doi.org/10.1186/1471-2407-11-321
ISSN
1471-2407
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의과대학 > 내과학교실 > Articles
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