Testosterone replacement therapy for late-onset hypogonadism: current trends in Korea

Title
Testosterone replacement therapy for late-onset hypogonadism: current trends in Korea
Author(s)
고영휘Kim, Je Jong[Kim, Je Jong]
Keywords
LOWER URINARY-TRACT; HEALTHY AGING MEN; ANDROGEN DEFICIENCY; SERUM TESTOSTERONE; OLDER MEN; CAVERNOUS VASODILATION; ERECTILE DYSFUNCTION; PROSTATE-CANCER; WHITE MEN; SYMPTOMS
Issue Date
201107
Publisher
SHANGHAI INST MATERIA MEDICA
Citation
ASIAN JOURNAL OF ANDROLOGY, v.13, no.4, pp.563 - 568
Abstract
Testosterone levels in men older than 40 years can decrease at a rate of 1%-2% per year, and reports show that more than 50% of 80-year-old men have testosterone levels consistent with hypogonadism. Late-onset hypogonadism (LOH) is a clinical and biochemical syndrome associated with advancing age and characterized by typical symptoms of serum testosterone deficiency. In recent decades, the concept of LOH in ageing men has become familiar in European countries and the United States. It is also a topic of interest and debate throughout Korea. However, most of the data regarding advantages or disadvantages of testosterone replacement therapy (TRT) as treatment for LOH have been primarily obtained from studies on Western populations; therefore, studies of the effects of TRT in Asian men, who may have different serum testosterone compared to Western men, are needed. TRT is commonly prescribed in Korea, despite the paucity of studies on the effects of TRT in Asian populations. Data from various TRT studies based on Korean have shown its efficacy in increasing serum testosterone levels and improving subjective symptoms as assessed by questionnaires. Currently, patches and short-acting intramuscular injections are displaced by gels and long-acting formulations. However, to prevent overdiagnosis and overtreatment, indication for TRT should include both low testosterone levels and symptoms and signs of hypogonadism. Asian Journal of Andrology (2011) 13, 563-568; doi: 10.1038/aja.2010.124; published online 16 May 2011
URI
http://hdl.handle.net/YU.REPOSITORY/24908http://dx.doi.org/10.1038/aja.2010.124
ISSN
1008-682X
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의과대학 > 비뇨기과학교실 > Articles
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