Quantitative determination of cefetamet in human plasma by liquid chromatography-mass spectrometry

Title
Quantitative determination of cefetamet in human plasma by liquid chromatography-mass spectrometry
Author(s)
노금한[노금한]김은영[김은영]강원구
Keywords
PIVOXIL
Issue Date
201107
Publisher
WILEY-BLACKWELL
Citation
BIOMEDICAL CHROMATOGRAPHY, v.25, no.7, pp.779 - 782
Abstract
Cefetamet is a potent antibiotic to treat respiratory and urinary tract infections. To improve oral bioavailability, it is administered as a prodrug, cefetamet pivoxyl hydrolyzed by esterase following absorption. A quantification method using a mass spectrometry was developed for the determination of cefetamet in human plasma. After a protein precipitation with acetonitrile, the analytes were chromatographed on a reversed-phase C(18) column and detected by a tandem mass spectrometer with electrospray ionization. The accuracy and precision of the assay were in accordance with FDA regulations for the validation of bioanalytical methods. This method was used to measure the concentrations of the cefetamet in plasma after a single oral administration of 500 mg cefetamet pivoxyl. Copyright (C) 2010 John Wiley & Sons, Ltd.
URI
http://hdl.handle.net/YU.REPOSITORY/24902http://dx.doi.org/10.1002/bmc.1516
ISSN
0269-3879
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약학대학 > 약학부 > Articles
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