Phylogeny-Guided Isolation of Ethyl Tumonoate A from the Marine Cyanobacterium cf. Oscillatoria margaritifera

Title
Phylogeny-Guided Isolation of Ethyl Tumonoate A from the Marine Cyanobacterium cf. Oscillatoria margaritifera
Author(s)
최혁재Niclas Engene[Niclas Engene]Eduardo Esquenazi[Eduardo Esquenazi]Tara Byrum[Tara Byrum]Francisco A. Villa[Francisco A. Villa]Zhengyu Cao[Zhengyu Cao]Thomas F. Murray[Thomas F. Murray]Pieter C. Dorrestein[Pieter C. Dorrestein]Lena Gerwick [Lena Gerwick ]William H. Gerwick[William H. Gerwick]
Keywords
NATURAL-PRODUCTS; LYNGBYA-MAJUSCULA; DIVERSITY; TAXONOMY; INSIGHTS; REAGENT; ORIGIN; ACIDS
Issue Date
201107
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF NATURAL PRODUCTS, v.74, no.8, pp.1737 - 1743
Abstract
The evolutionary relationships of cyanobacteria, as inferred by their SSU (16S) rRNA genes, were used as predictors of their potential to produce varied secondary metabolites. The evolutionary relatedness in geographically distant cyanobac:terial specimens was then used as a guide for the detection and isolation of new variations of predicted molecules. This phylogeny-guided isolation approach for new secondary metabolites was tested in its capacity to direct the search for specific classes of new natural products from Curacao marine cyanobacteria. As a result, we discovered ethyl tumonoate A (1), a new timonoic acid derivative with anti-inflammatory activity and inhibitory activity of calcium oscillations in neocortical neurons.
URI
http://hdl.handle.net/YU.REPOSITORY/24885http://dx.doi.org/10.1021/np200236c
ISSN
0163-3864
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약학대학 > 약학부 > Articles
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