Full metadata record

DC FieldValueLanguage
dc.contributor.author최형철ko
dc.contributor.author김정은ko
dc.contributor.author성진영ko
dc.contributor.author우창훈ko
dc.contributor.author강영진ko
dc.contributor.author이광윤ko
dc.contributor.author김희선ko
dc.contributor.author권우형ko
dc.date.accessioned2015-12-17T01:19:09Z-
dc.date.available2015-12-17T01:19:09Z-
dc.date.created2015-11-13-
dc.date.issued201108-
dc.identifier.citationKOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.15, no.4, pp.203 - 210-
dc.identifier.issn1226-4512-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/24812-
dc.identifier.urihttp://dx.doi.org/10.4196/kjpp.2011.15.4.203-
dc.description.abstractCilostazol is a selective inhibitor of phosphodiesterase 3 that increases intracellular CAMP levels and activates protein kinase A, thereby inhibiting vascular smooth muscle cell (VSMC) proliferation. We investigated whether AMP-activated protein kinase (AMPK) activation induced by heme oxygenase-1 (HO-1) is a mediator of the beneficial effects of cilostazol and whether cilostazol may prevent cell proliferation and reactive oxygen species (ROS) production by activating AMPK in VSMC. In the present study, we investigated VSMC with various concentrations of cilostazol. Treatment with cilostazol increased HO-1 expression and phosphorylation of AMPK in a dose- and time-dependent manner. Cilostazol also significantly decreased platelet-derived growth factor (PDGF)-induced VSMC proliferation and ROS production by activating AMPK induced by HO-1. Pharmacological and genetic inhibition of HO-1 and AMPK blocked the cilostazol-induced inhibition of cell proliferation and ROS production.These data suggest that cilostazol-induced HO-1 expression and AMPK activation might attenuate PDGF-induced VSMC proliferation and ROS production.-
dc.language영어-
dc.publisherKOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY-
dc.subjectFATTY-ACID OXIDATION-
dc.subjectTHERAPEUTIC TARGET-
dc.subjectHYPERTENSIVE-RATS-
dc.subjectGLUCOSE-UPTAKE-
dc.subjectGROWTH-
dc.subjectDISEASE-
dc.subjectADIPONECTIN-
dc.subjectEXPRESSION-
dc.subjectSYSTEM-
dc.subjectGENE-
dc.titleCilostazol Inhibits Vascular Smooth Muscle Cell Proliferation and Reactive Oxygen Species Production through Activation of AMP-activated Protein Kinase Induced by Heme Oxygenase-1-
dc.typeArticle-
dc.identifier.wosid000294930800003-
dc.identifier.scopusid2-s2.0-80052871492-
Appears in Collections:
의과대학 > 약리학교실 > Articles
의과대학 > 미생물학교실 > Articles
의과대학 > 성형외과학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE