Diffusion tensor imaging findings in neurologically asymptomatic patients with end stage renal disease

Title
Diffusion tensor imaging findings in neurologically asymptomatic patients with end stage renal disease
Author(s)
장성호김한선박종원배대석정진영홍지헌[홍지헌]손수민
Keywords
CHRONIC KIDNEY-DISEASE; COGNITIVE IMPAIRMENT; AXONAL INJURY; SPATIAL AWARENESS; BRAIN NETWORKS; TRACTOGRAPHY; DIALYSIS; HEMODIALYSIS; TRACKING; FAILURE
Issue Date
201108
Publisher
IOS PRESS
Citation
NEUROREHABILITATION, v.29, no.1, pp.111 - 116
Abstract
Various neurological problems of the brain are known to occur in patients with end stage renal disease (ESRD). However, little is known about diffusion tensor imaging (DTI) findings in patients with ESRD. Using DTI, we attempted to investigate DTI findings in patients with ESRD who showed no specific lesions on conventional brain MRI. We recruited 10 consecutive patients with ESRD for whom at least 3 years had passed since the start of peritoneal dialysis and who showed no neurological abnormality on neurologic examination. We excluded 6 patients who showed cerebral infarct (4 patients) and diabetes mellitus with peripheral neuropathy (2 patients); finally, 4 patients (39.75 +/- 9.84 years) were included in this study. We evaluated hand motor function and cognition. DTI data were acquired using a 1.5-T Philips Gyroscan Intera system and diffusion tensor tractographies (DTTs) for five neural tracts (corticospinal tract, fornix, superior longitudinal fasciculus, inferior longitudinal fasciculus, and inferior fronto-occipital fasciculus) were evaluated. With the exception of 1 patient who revealed a mild abnormality at a higher cognitive function, no abnormalities in motor and cognitive function were observed. Among the 10 DTTs, except for those of the corticospinal tract, all 4 patients had more than one lesion. Patients with ESRD showed abnormalities on DTTs that were associated with cognition; however, they did not show significant cognitive abnormalities.
URI
http://hdl.handle.net/YU.REPOSITORY/24806http://dx.doi.org/10.3233/NRE-2011-0684
ISSN
1053-8135
Appears in Collections:
의과대학 > 재활의학교실 > Articles
의과대학 > 내과학교실 > Articles
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