NADPH oxidase inhibitors: a patent review

Title
NADPH oxidase inhibitors: a patent review
Author(s)
김정애거네스퍼러사더네오파네이응석정병선박병철프리텀다빠
Keywords
SMOOTH-MUSCLE-CELLS; CHRONIC GRANULOMATOUS-DISEASE; VASCULAR NAD(P)H OXIDASES; REACTIVE OXYGEN; NOX FAMILY; HOST-DEFENSE; SUPEROXIDE-PRODUCTION; DIABETIC-NEPHROPATHY; HYDROGEN-PEROXIDE; OXIDATIVE STRESS
Issue Date
201108
Publisher
INFORMA HEALTHCARE
Citation
EXPERT OPINION ON THERAPEUTIC PATENTS, v.21, no.8, pp.1147 - 1158
Abstract
Introduction: NADPH oxidases, a family of multi-subunit enzyme complexes, catalyze the production of reactive oxygen species (ROS), which may contribute to the pathogenesis of a variety of diseases. In addition to the first NADPH oxidase found in phagocytes, four non-phagocytic NADPH oxidase isoforms have been identified, which all differ in their catalytic subunit (Nox1-5) and tissue distribution. Areas covered: This paper provides a comprehensive review of the patent literature on NADPH oxidase inhibitors, small molecule Nox inhibitors, peptides and siRNAs. Expert opinion: Since each member of the NADPH oxidase family has great potential as a therapeutic target, several different compounds have been registered as NADPH oxidase inhibitors in the patent literature. As yet, none have gone through clinical trials, and some have not completed preclinical trials, including safety and specificity evaluation. Recently, small molecule pyrazolopyridine and triazolopyrimidine derivatives have been submitted as potent NADPH oxidase inhibitors and reported as first-in-class inhibitors for idiopathic pulmonary fibrosis and acute stroke, respectively. Further clinical efficacy and safety data are warranted to prove their actual clinical utility.
URI
http://hdl.handle.net/YU.REPOSITORY/24797http://dx.doi.org/10.1517/13543776.2011.584870
ISSN
1354-3776
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약학대학 > 약학부 > Articles
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