Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship

Title
Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship
Author(s)
우떰다빠[우떰다빠]프리텀다빠라다깔끼윤민호[윤민호]최재훈[최재훈]장영동이은영[이은영]전경화[전경화]나영화[나영화]하은미[하은미]조원제[조원제]권영주[권영주]이응석
Keywords
2,4,6-TRISUBSTITUTED PYRIDINE; DNA TOPOISOMERASES; NUCLEASE ACTIVITY; DERIVATIVES; CELLS; COMPLEXES; CHROMENE
Issue Date
201108
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.46, no.8, pp.3201 - 3209
Abstract
Designed and synthesized were a series of 5H-chromeno[4,3-b]pyridines with substitution at 2- and 4-positions with various 5- or 6-membered heteroaromatics as antitumor agents. They were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Structure activity relationship study showed that 2-furyl or 2-thienyl at 2- or 4-position of central pyridine is crucial in displaying topo I or II inhibitory activity and cytotoxicity. (C) 2011 Elsevier Masson SAS. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/24794http://dx.doi.org/10.1016/j.ejmech.2011.04.029
ISSN
0223-5234
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약학대학 > 약학부 > Articles
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