Clinical outcomes of mild hyperthermia for locally advanced rectal cancer treated with preoperative radiochemotherapy

Title
Clinical outcomes of mild hyperthermia for locally advanced rectal cancer treated with preoperative radiochemotherapy
Author(s)
강민규김명세김재황
Keywords
SOFT-TISSUE SARCOMAS; PROGNOSTIC-FACTORS; TUMOR OXYGENATION; RANDOMIZED-TRIAL; RADIOTHERAPY; 5-FLUOROURACIL; SURGERY; CELLS; CHEMORADIOTHERAPY; CHEMORADIATION
Issue Date
201108
Publisher
INFORMA HEALTHCARE
Citation
INTERNATIONAL JOURNAL OF HYPERTHERMIA, v.27, no.5, pp.482 - 490
Abstract
Purpose: The aim of this report was to determine the impact of hyperthermia (HT) on preoperative radiochemotherapy for locally advanced rectal cancer. Materials and methods: Between 1996 and 2007, 235 patients with locally advanced rectal cancer were treated with concurrent preoperative radiochemotherapy with or without HT. The total dose of radiotherapy was 39.6 Gy for 109 patients (group A) and 45 Gy for 126 patients (group B). Two or three cycles of chemotherapy were administered. Hyperthermia was given immediately after radiotherapy. Results: In the HT subgroup of group A, more patients achieved down-staging of T stage when compared to the non-HT subgroup (57.9% versus 38%, p = 0.047). For the cN+ subgroup of all patients, the number of patients with ypN+ were significantly less in the HT subgroup (25% versus 50%, p = 0.022). In group A, HT appeared to reduce distant metastasis, increase disease-free survival, and improve overall survival. Conclusions: HT seemed to increase the response of both primary tumour and lymph nodes to preoperative radiochemotherapy in patients with locally advanced rectal cancer. The relationship between increased response by HT and survival should be confirmed by a large prospective randomised trial.
URI
http://hdl.handle.net/YU.REPOSITORY/24785http://dx.doi.org/10.3109/02656736.2011.563769
ISSN
0265-6736
Appears in Collections:
의과대학 > 방사선종양학교실 > Articles
의과대학 > 성형외과학교실 > Articles
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