Recombinant mussel adhesive protein fp-5 (MAP fp-5) as a bulk bioadhesive and surface coating material

Title
Recombinant mussel adhesive protein fp-5 (MAP fp-5) as a bulk bioadhesive and surface coating material
Author(s)
김창섭최유성[최유성]강동균[강동균]임성혜[임성혜]양윤정[양윤정]차형준[차형준]
Keywords
MYTILUS-EDULIS; SOLUBILITY; ATTACHMENT; STRENGTH; CALIFORNICA; CHEMISTRY
Issue Date
201108
Publisher
TAYLOR & FRANCIS LTD
Citation
BIOFOULING, v.27, no.7, pp.729 - 737
Abstract
Mussel adhesive proteins (MAPs) attach to all types of inorganic and organic surfaces, even in wet environments. MAP of type 5 (fp-5), in particular, has been considered as a key adhesive material. However, the low availability of fp-5 has hampered its biochemical characterization and practical applications. Here, soluble recombinant fp-5 is mass-produced in Escherichia coli. Tyrosinase-modified recombinant fp-5 showed similar to 1.11 MPa adhesive shear strength, which is the first report of a bulk-scale adhesive force measurement for purified recombinant of natural MAP type. Surface coatings were also performed through simple dip-coating of various objects. In addition, complex coacervate using recombinant fp-5 and hyaluronic acid was prepared as an efficient adhesive formulation, which greatly improved the bulk adhesive strength. Collectively, it is expected that this work will enhance basic understanding of mussel adhesion and that recombinant fp-5 can be successfully used as a realistic bulk-scale bioadhesive and an efficient surface coating material.
URI
http://hdl.handle.net/YU.REPOSITORY/24765http://dx.doi.org/10.1080/08927014.2011.600830
ISSN
0892-7014
Appears in Collections:
이과대학 > 화학생화학부 > Articles
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