Effect of Saucerneol D on Melanin Production in cAMP-Elevated Melanocytes

Title
Effect of Saucerneol D on Melanin Production in cAMP-Elevated Melanocytes
Author(s)
손종근윤지영[윤지영]노은미리[노은미리]이승호서창섭[서창섭]황방연[황방연]한상배[한상배]김영수[김영수]
Keywords
MICROPHTHALMIA GENE-PRODUCT; NF-KAPPA-B; SAURURUS-CHINENSIS; TRANSCRIPTION FACTOR; TYROSINASE; PIGMENTATION; EXPRESSION; LIGNANS; MECHANISM; CELLS
Issue Date
201108
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.34, no.8, pp.1339 - 1345
Abstract
Intracellular cAMP stimulates microphthalmia-associated transcription factor (MITE) induction in melanocytes through cAMP-responsive element binding protein (CREB), which plays a pivotal role in the gene expression of tyrosinase for melanin biosynthesis. In the present study, saucerneol D as a lignan constituent of Saururus chinensis (Saururaceae family) efficiently inhibited melanin production with IC(50) values of 188-297 nM in B16 melanoma cells stimulated with a-melanocyte stimulating hormone (alpha-MSH) or other cAMP elevators. Moreover, saucerneol D down-regulated alpha-MSH-induced gene expression of tyrosinase at the transcription level in B16 cells, but it did not directly inhibit the catalytic activity of cell-free tyrosinase. As to the molecular basis of hypopigmenting action, saucerneol D inhibited alpha-MSH-induced phosphorylation of CREB in the cells, and sequentially suppressed MITF induction. Taken together, this study provides saucerneol D down-regulated the gene expression of tyrosinase, resulting in the inhibition of cAMP-induced melanin biosynthesis, and suggests pharmacological potential of the lignan structure in skin hyperpigmentation.
URI
http://hdl.handle.net/YU.REPOSITORY/24755http://dx.doi.org/10.1007/s12272-011-0814-8
ISSN
0253-6269
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약학대학 > 약학부 > Articles
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