β-Carotene의 섭취가 당뇨 유도 흰쥐의 간조직 항산화효소 활성과 Glutathione 함량에 미치는 영향

Title
β-Carotene의 섭취가 당뇨 유도 흰쥐의 간조직 항산화효소 활성과 Glutathione 함량에 미치는 영향
Other Titles
Effect of Dietary Supplementation of β-Carotene on Hepatic Antioxidant Enzyme Activities and Glutathione Concentration in Diabetic Rats
Author(s)
서정숙장정현[장정현]이경순[이경순]
Keywords
β-carotene; diabetic rat; antioxidative enzyme; glutathione
Issue Date
201108
Publisher
한국식품영양과학회
Citation
한국식품영양과학회지, v.40, no.8, pp.1092 - 1098
Abstract
The present study was conducted to investigate the effect of β-carotene on the antioxidant system of rats with diabetes. Forty Sprague Dawley rats were fed the AIN-76 control diet or the same diet supplemented with β-carotene (7.2 mg/kg diet) for 3 weeks, then diabetes was induced in half the rats by administering streptozotocin (45 mg/kg BW) into the femoral muscle. Diabetic and normal rats were fed the experimental diets for 2 more weeks. To investigate the effect of dietary β-carotene on diabetes, the activities of antioxidative enzymes and glutathione concentration were determined in normal and streptozotocin-induced diabetic rats. The plasma glucose levels in diabetic rats were not influenced by the dietary supplementation of β-carotene. Hepatic activities of catalase and superoxide dismutase in diabetic rats were significantly lower than those of control rats but β-carotene tended to induce these activities. Glutathione-S-transferase activity was not significantly different between experimental groups. Glucose-6-phosphatase activity was induced in diabetic rats, but dietary supplementation of β-carotene reduced this activity. The hepatic concentration of reduced glutathione in diabetic rats was lower than that of control rats, but dietary supplementation with β-carotene restored the content to some extent. These data suggest that diabetic rats are exposed to increased oxidative stress and that dietary supplementation with β-carotene may reduce its detrimental effects.
URI
http://hdl.handle.net/YU.REPOSITORY/24712
ISSN
1226-3311
Appears in Collections:
생활과학대학 > 식품영양학과 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE