Preparation and in vivo Evaluation of a Sildenafil Lactate-loaded Solid Self-emulsifying Drug Delivery System

Title
Preparation and in vivo Evaluation of a Sildenafil Lactate-loaded Solid Self-emulsifying Drug Delivery System
Author(s)
용철순정시영[정시영]김동욱[김동욱]이동원[이동원]우종수[우종수]김종오최한곤[최한곤]
Keywords
Sildenafil lactate; SEDDS; Immediate erection; Pharmacokinetics
Issue Date
201108
Publisher
한국약제학회
Citation
Journal of Pharmaceutical Investigation, v.41, no.4, pp.249 - 253
Abstract
To develop a sildenafil lactate-loaded solid self-emulsifying drug delivery system (SEDDS) with a fast onset of action and immediate action of erection, sildenafil lactate (0.3 g), which was prepared using a spray dryer, was dissolved in 4.7 g of the mixture of glyceryl monooleate/Transcutol/ Tween 20 (3/0.5/1, g). Its emulsion droplet size and pharmacokinetics in rabbits were evaluated compared with sildenafil citrate-loaded commercial tablet. The sildenafil lactateloaded SEDDS showed an emulsion droplet size of about 300 nm. In pharmacokinetics study, it gave significantly faster Tmax than did the commercial tablet. Thus, the sildenafil lactate-loaded SEDDS at the one-third drug dose compared to sildenafil citrate-loaded conventional tablet might induce a fast onset of action and immediate erection without enhanced bioavailability compared with the sildenafil citrate-loaded commercial tablet.
URI
http://hdl.handle.net/YU.REPOSITORY/24703
ISSN
2093-5552
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약학대학 > 약학부 > Articles
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