불가사리 부타놀 분획의 항알러지 활성

Title
불가사리 부타놀 분획의 항알러지 활성
Other Titles
Anti-allergic Activity of Butanol Fraction of Asterias amurensis
Author(s)
장현욱양주혜[양주혜]나민균
Keywords
Asterias amurensis; mouse bone marrow-derived mast cells; cyclooxygenase-2; 5-lipoxygenase; anti-allergic effect
Issue Date
201108
Publisher
대한약학회
Citation
약 학 회 지, v.55, no.4, pp.295 - 300
Abstract
We investigated the effects of butanol fraction of Asterias amurensis (BFA) on the anti-allergic activity. BFA inhibited both cyclooxygenase-2 dependent prostaglandin D_2 and 5-lipoxygenase dependent leukotriene C_4 generation in a concentration-dependent manner with IC_50 values of 174.6 and 22.2 μg/ml, respectively. In addition, BFA also inhibited the degranulation in a dose dependent manner. Furthermore, oral administration of BFA inhibited IgE-mediated passive cutaneous anaphylaxis in mice. These results suggested that BFA may be useful in regulating mast cell-mediated allergic diseases.
URI
http://hdl.handle.net/YU.REPOSITORY/24695
ISSN
0377-9556
Appears in Collections:
약학대학 > 약학부 > Articles
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