Temperature and pH Stability Profiles of ortho and para DEET

Title
Temperature and pH Stability Profiles of ortho and para DEET
Author(s)
용철순김정선[김정선]최미린[최미린]김석용[김석용]최준호[최준호]박상희[박상희]
Keywords
DEET; Temperature stability; pH stability; Mosquito repellency
Issue Date
201108
Publisher
한국약제학회
Citation
Journal of Pharmaceutical Investigation, v.41, no.4, pp.233 - 238
Abstract
DEET, N,N’-diethyl-m-toluamide, is the most commonly used mosquito repellent. However, it can easily permeate through skin leading to toxic effects. A recent study showed that the ortho analogue of DEET showed enhanced repellency with reduced permeation compared to the commercially used meta analogue. Thus, in order to understand the differences in properties and effectiveness among the m-, o- and p-analogues of DEET, an HPLC-UV method was developed for separately analyzing the three analogues. Moreover, stability profiles at temperatures ranging from 30oC to 70oC as well as pH ranging from pH 3 to pH 9 have been determined. All three analogues were stable with no degradation observed during the 5 day period. o-DEET therefore could be further developed into a safer and more effective mosquito repellent.
URI
http://hdl.handle.net/YU.REPOSITORY/24672
ISSN
2093-5552
Appears in Collections:
약학대학 > 약학부 > Articles
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