Protective Constituents against Sepsis in Mice from the Root Barks of Ulmus davidiana var. japonica

Title
Protective Constituents against Sepsis in Mice from the Root Barks of Ulmus davidiana var. japonica
Author(s)
손종근정명선이호[이호]이응서창섭이연경정전섭[정전섭]송동근[송동근]배홍범[배홍범]곽상현[곽상현]장현욱김재룡
Keywords
TUMOR-NECROSIS-FACTOR; PLANCH ULMACEAE; NITRIC-OXIDE; INNER BARK; GLYCOSIDES; INHIBITION; SHOCK; CELLS; ACTIVATION; FRACTION
Issue Date
201109
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.34, no.9, pp.1443 - 1450
Abstract
In the course of isolating preventive agents against sepsis based on the in vivo assay model, eleven known compounds, (-)-catechin (1), catechin-7-O-beta-apiofuranoside (2), catechin-7-O-alpha-L-rhamnopyranoside (3), catechin-3-O-alpha-L-rhamnopyranoside (4), catechin-7-O-beta-D-glucopyranoside (5), butyl (+)-5'-methoxyisolariciresinol-9'-O-beta-D-xylopyranoside (6), lyoniside (7), nudipo-side (8), alpha-nigerose (9), butyl alpha-D-fructofuranoside (10), and procyanidin B(3) (11) were isolated from the root barks of Ulmus davidiana var. japonica. Compounds 2, 6, and 8 significantly protected against sepsis in a mouse model with survival rates of mice exposed to 10 mg/kg of LPS/D-GalN ranged from 80%-100%. Among them, 8 exhibited the most potent protective effect and decreased the plasma levels of TNF-alpha, IL-10 and ALT activity.
URI
http://hdl.handle.net/YU.REPOSITORY/24618http://dx.doi.org/10.1007/s12272-011-0905-6
ISSN
0253-6269
Appears in Collections:
약학대학 > 약학부 > Articles
의과대학 > 생화학.분자생물학교실 > Articles
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