Suppression of dust mite extract and 2,4-dinitrochlorobenzene-induced atopic dermatitis by the water extract of Lindera obtusiloba

Title
Suppression of dust mite extract and 2,4-dinitrochlorobenzene-induced atopic dermatitis by the water extract of Lindera obtusiloba
Author(s)
이승호최은주[최은주]이소영[이소영]김희훈[김희훈]Taudam S.K.[Taudam S.K.]최진경[최진경]최현규서원모김상현[김상현]
Keywords
NC/NGA MICE; ALLERGIC INFLAMMATION; ARTEMISIA-ASIATICA; HISTAMINE-RELEASE; SKIN-LESIONS; MAST-CELLS; T-CELLS; MACROPHAGES; INHIBITION; DISORDERS
Issue Date
201109
Publisher
ELSEVIER IRELAND LTD
Citation
JOURNAL OF ETHNOPHARMACOLOGY, v.137, no.1, pp.802 - 807
Abstract
Ethnopharmacological relevance: The Lindera obtusiloba has been used in traditional medicine for the treatment of inflammation and dermatitis. In this study, we investigated the effect of topical application of Lindera obtusiloba water extract (LOWE) on the house dust mite extract (Dermatophagoides farinae extract. DFE) and 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). Materials and methods: We established AD model in BALB/c mice by repeated local exposure of DFE/DNCB to the ears. After a topical application of LOWE on the skin lesions, the epidermal thickness, mast cell infiltration, and serum immunoglobulin E (IgE) and histamine were measured. In addition, the gene expression of interleukin (IL)-4, IL-13,IL-31, and tumor necrosis factor (TNE)-alpha in the ears was assayed. Results: LOWE reduced AD symptoms based on ear thickness, histopathological analysis, and serum IgE levels. LOWE inhibited mast cell infiltration into the ear and elevation of serum histamine in AD model. Moreover. LOWE suppressed DFE/DNCB-induced expression of IL-4, IL-13, IL-31, and TNF-alpha in the ears. Conclusions: Our results showed that topical application of LOWE exerts beneficial effects in AD symptoms, suggesting that LOWE might be a candidate for the treatment of AD. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/24606http://dx.doi.org/10.1016/j.jep.2011.06.043
ISSN
0378-8741
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약학대학 > 약학부 > Articles
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