A Multicenter, Randomized, Comparative Study to Determine the Appropriate Dose of Lansoprazole for Use in the Diagnostic Test for Gastroesophageal Reflux Disease

Title
A Multicenter, Randomized, Comparative Study to Determine the Appropriate Dose of Lansoprazole for Use in the Diagnostic Test for Gastroesophageal Reflux Disease
Author(s)
이시형장병익전성우[전성우]권중구[권중구]김은영[김은영]조광범[조광범]박창근[박창근]양창헌[양창헌]
Keywords
EROSIVE ESOPHAGITIS; CLINICAL SPECTRUM; OMEPRAZOLE TEST; PREVALENCE; POPULATION; KOREA; PH
Issue Date
201109
Publisher
EDITORIAL OFFICE GUT & LIVER
Citation
GUT AND LIVER, v.5, no.3, pp.302 - 307
Abstract
Background/Aims: The diagnostic proton pump inhibitor test (PPI test) is a method used in diagnosing gastroesophageal reflux disease (GERD). This study aimed to determine the appropriate dose of lansoprazole for use in the diagnostic test for GERD. Methods: This study was a randomized, controlled, multicenter trial in the Daegu-Gyeongbuk area. Patients with typical reflux symptoms such as regurgitation and heartburn for at least three months were enrolled in this study. Patients were divided into two groups, the erosive reflux disease (ERD) group and the non-erosive reflux disease (NERD) group, and randomized to 14 days of treatment with lansoprazole at a dose of 15 mg, 30 mg or 60 mg once daily. The PPI test was considered positive if the patient's symptoms improved by more than 50%. Results: A total of 218 patients were enrolled, and analysis was performed on the 188 patients who completed the study. The PPI test was positive in 93.2% of the ERD group and 87.2% of the NERD group. A positive PPI test was observed in 91.7%, 89.4%, and 87.2% of the 15 mg, 30 mg, and 60 mg groups, respectively. Significant symptom score changes were observed starting on day 8 for the 15 mg, 30 mg, and 60 mg groups. Conclusions: In this multicenter, randomized study of Korean patients, the standard dose of lansoprazole was as effective as a high dose of lansoprazole in relieving the symptoms of GERD, regardless of the presence of ERD, by day 14 of treatment. (Gut Liver 201145:302-307)
URI
http://hdl.handle.net/YU.REPOSITORY/24603http://dx.doi.org/10.5009/gnl.2011.5.3.302
ISSN
1976-2283
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의과대학 > 내과학교실 > Articles
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