Chiral separation of basic compounds on a cellulose 3,5-dimethylphenylcarbamate-coated zirconia monolithin basic eluents by capillary electrochromatography
- Chiral separation of basic compounds on a cellulose 3,5-dimethylphenylcarbamate-coated zirconia monolithin basic eluents by capillary electrochromatography
- 박정학; 프라빈쿠마르
- PERFORMANCE LIQUID-CHROMATOGRAPHY; 2,4-DINITROPHENYL AMINO-ACIDS; CARBON-CLAD ZIRCONIA; STATIONARY PHASES; POLYSACCHARIDE DERIVATIVES; COATED ZIRCONIA; SILICA-GEL; ENANTIOMER SEPARATION; IMMOBILIZED ZIRCONIA; CONTINUOUS BEDS
- Issue Date
- ELSEVIER SCIENCE BV
- JOURNAL OF CHROMATOGRAPHY A, v.1218, no.37, pp.6548 - 6553
- Porous zirconia monolith (ZM) modified with cellulose 3,5-dimethylphenylcarbamate (CDMPC) was used as chiral stationary phaseto separate basic chiral compounds in capillary electrochromatography. The electroosmotic flow behavior of bare and CDMPC-modified zirconia monolithic (CDMPC-ZM) column was studied in ACN/phosphate buffer eluents of pH ranging from 2 to 12. The CDMPC-ZM column was evaluated by investigatingthe influences of pH, the type and composition of organic modifier of the eluent on enantioseparation. CEC separations at pH 9 provided the best resolutions for the analytes studied, which are better than those observed on CDMPC-modified silica monolithic columns under similar chromatographic conditions. No appreciable decline in retention and resolution factors after over 200 injections, and run-to-run and day-to-day repeatabilities of the column of less than 3% indicate the stability of the zirconia monolithic column in basic media. (C) 2011 Elsevier B.V. All rights reserved.
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