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dc.contributor.author장현욱ko
dc.contributor.authorMeihua Jin[Meihua Jin]ko
dc.contributor.author양주혜[양주혜]ko
dc.contributor.author조태형[조태형]ko
dc.contributor.author박영인[박영인]ko
dc.contributor.author이종길[이종길]ko
dc.contributor.author박상조[박상조]ko
dc.contributor.author손건호[손건호]ko
dc.contributor.author유예[유예]ko
dc.date.accessioned2015-12-17T01:14:43Z-
dc.date.available2015-12-17T01:14:43Z-
dc.date.created2015-11-13-
dc.date.issued201109-
dc.identifier.citationARCHIVES OF PHARMACAL RESEARCH, v.34, no.9, pp.1495 - 1501-
dc.identifier.issn0253-6269-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/24576-
dc.identifier.urihttp://dx.doi.org/10.1007/s12272-011-0911-8-
dc.description.abstract6-Hydroxy-2,7-dimethoxy-1,4-phenanthraquinone (PAQ) isolated from the tuberous roots of Yam (Dioscorea batatas) inhibited cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1) dependent prostaglandin D-2 (PGD(2)) generation in mouse bone marrow-derived mast cells in a concentration-dependent manner with IC50 values of 0.08 mu M and 0.27 mu M, respectively. In the Western blotting with specific anti-COX-2 antibodies, the decrease of the quantity of PGD(2) was accompanied by a decrease in the COX-2 protein level. But PAQ did not affect COX-1 protein level. In addition, this compound inhibited 5-lipoxygenase (5-LOX) dependent production of leukotriene C-4 in a dose-dependent manner, with an IC50 of 0.032 mu M. These results demonstrate that PAQ has a dual COX-2/5-LOX inhibitory activity. This compound also inhibited the degranulation reaction in a dose-dependent manner with an IC50 of 2.7 mu M. Thus, these results suggest that PAQ may be useful in regulating mast cell-mediated inflammatory diseases.-
dc.language영어-
dc.publisherPHARMACEUTICAL SOC KOREA-
dc.subjectNF-KAPPA-B-
dc.subjectOCCUPATIONAL ASTHMA-
dc.subjectANTIOXIDANT ACTIVITIES-
dc.subjectPINELLIA-TERNATA-
dc.subjectDUAL INHIBITORS-
dc.subjectRAW264.7 CELLS-
dc.subject5-LIPOXYGENASE-
dc.subjectEXPRESSION-
dc.subjectCYCLOOXYGENASES-2-
dc.subjectDIOSCIN-
dc.titleAnti-inflammatory Activity of 6-Hydroxy-2,7-dimethoxy-1,4-henanthraquinone from Tuberous Roots of Yam (Dioscorea batatas) through Inhibition of Prostaglandin D-2 and Leukotriene C-4 Production in Mouse Bone Marrow-derived Mast Cells-
dc.typeArticle-
dc.identifier.wosid000295825600013-
dc.identifier.scopusid2-s2.0-80755125537-
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