Topoisomerase I and II Inhibitory Activities and Cytotoxic Constituents from the Barks of Tilia amurnesis

Title
Topoisomerase I and II Inhibitory Activities and Cytotoxic Constituents from the Barks of Tilia amurnesis
Author(s)
손종근박동근이유정서창섭이종순김재룡장현욱
Keywords
Cytotoxicity; DNA topoisomerases I; DNA topoisomerases II; Tilia amurensis
Issue Date
201109
Publisher
한국생약학회
Citation
Natural Product Sciences, v.17, no.3, pp.245 - 249
Abstract
Eight compounds, squalene (1), friedelin (2), b-sitosterol (3), b-sitosterol-3-O-glucoside (4), a-tocopherol (5), betulinic acid (6), trilinolein (7) and 1-O-(9Z,12Z-Octadecadienoyl)-3-nonadecanoyl glycerol (8), were isolated from the barks of Tilia amurensis. Their chemical structures were identified by comparing their physicochemical and spectral data with those published in the literature. These isolated compounds were examined for their inhibitory activities against topoisomerase I and II. Compound 7 showed significant inhibition of DNA topoisomerase I and II activities, with percent decreases in activity of 87 and 95%, respectively at a concentration of 100 mM. Compound 6 exhibited cytotoxicity against the human colon adenocarcinoma cell line (HT-29), the human breast adenocarcinoma cell line (MCF-7) and the human liver hepatoblastoma cell line (HepG-2), with IC50 values of 20, 59 and 16 mM, respectively.
URI
http://hdl.handle.net/YU.REPOSITORY/24536
ISSN
1226-3907
Appears in Collections:
약학대학 > 약학부 > Articles
이과대학 > 화학생화학부 > Articles
의과대학 > 생화학.분자생물학교실 > Articles
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