Peginterferon alpha and ribavirin combination therapy in patients with hepatitis C virus-related liver cirrhosis

Title
Peginterferon alpha and ribavirin combination therapy in patients with hepatitis C virus-related liver cirrhosis
Author(s)
이헌주Kim KH[Kim KH]장병국[장병국]환재석[환재석]권영오[권영오]탁원영[탁원영]이창형[이창형]서정일[서정일]
Keywords
Pegylated interferon; Ribavirin; Hepatitis C; Cirrhosis
Issue Date
201109
Publisher
대한간학회
Citation
Clinical and Molecular Hepatology, v.17, no.3, pp.220 - 225
Abstract
Background/Aims: Pegylated interferon (peginterferon) and ribavirin combination therapy is less effective and associated with a higher frequency of serious complications in chronic hepatitis C patients with cirrhosis than in noncirrhotic patients. This study evaluated the efficacy and tolerability of peginterferon and ribavirin treatment in patients with hepatitis C virus (HCV)-related cirrhosis. Methods: Eighty-six patients with clinically diagnosed liver cirrhosis were treated with either peginterferon alpha-2a (n=51) or peginterferon alpha-2b (n=35) plus ribavirin. The sustained virologic response (SVR) and adverse effects were analyzed retrospectively. Results: Of the 86 patients (55 males), 48 patients (55.8%) had HCV genotype 1 infection and 38(44.2%) had genotype non-1 infection. The overall SVR rate was 34.9% (30/86), and the rates of SVR in the genotype 1 and non-1 patients were 20.8% (10/48) and 52.6% (20/38), respectively. The multivariate analysis revealed that having HCV genotype 1 (P=0.003) and high baseline viral load (>8.0×105 IU/mL, P=0.012) were the independent predictive factors for SVR failure. In 20.9% (18/86) of the patients, treatment was not completed due to adverse events (27.8%), loss to follow-up (50.0%),and other reasons (22.2%). Conclusions: Peginterferon and ribavirin combination therapy was relatively effective and feasible for clinically diagnosed HCV patients, especially in those with genotype non-1 infection and low baseline viral load.
URI
http://hdl.handle.net/YU.REPOSITORY/24507
ISSN
2287-2728
Appears in Collections:
의과대학 > 내과학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE