Solid self-nanoemulsifying drug delivery system (S-SNEDDS) containing phosphatidylcholine for enhanced bioavailability of highly lipophilic bioactive carotenoid lutein

Title
Solid self-nanoemulsifying drug delivery system (S-SNEDDS) containing phosphatidylcholine for enhanced bioavailability of highly lipophilic bioactive carotenoid lutein
Author(s)
유봉규스리니바산 샨무감[스리니바산 샨무감]렌가라잔 바스카란[렌가라잔 바스카란]프라바가 발라크리쉬난[프라바가 발라크리쉬난]프리텀 따파[프리텀 따파]용철순
Keywords
LIPID-BASED FORMULATIONS; CATARACT-EXTRACTION; MACULAR PIGMENT; ORAL DELIVERY; DISSOLUTION; ABSORPTION; RISK; SOLUBILITY; PLASMA; SEDDS
Issue Date
201110
Publisher
ELSEVIER SCIENCE BV
Citation
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v.79, no.2, pp.250 - 257
Abstract
The objectives of this study was to prepare solid self-nanoemulsifying drug delivery system (S-SNEDDS) containing phosphatidylcholine (PC), an endogenous phospholipid with excellent in vivo solubilization capacity, as oil phase for the delivery of bioactive carotenoid lutein, by spray drying the SNEDDS (liquid system) containing PC using colloidal silica (Aerosil (R) 200 VV Pharma) as the inert solid carrier, and to evaluate the enhanced bioavailability (BA) of lutein from S-SNEDDS. The droplet size analyses revealed droplet size of less than 100 nm. The solid state characterization of S-SNEDDS by SEM, DSC, and XRPD revealed the absence of crystalline lutein in the S-SNEDDS. The bioavailability study performed in rabbits resulted in enhanced values of C-max and AUC for S-SNEDDS. The enhancement of C-max for S-SNEDDS was about 21-folds and 8-folds compared with lutein powder (LP) and commercial product (CP), respectively. The relative BA of S-SNEDDS compared with CP or LP was 2.74-folds or 11.79-folds, respectively. These results demonstrated excellent ability of S-SNEDDS containing PC as oil phase to enhance the BA of lutein in rabbits. Thus, S-SNEDDS containing PC as oil phase could be a useful lipid drug delivery system for enhancing the BA of lutein in vivo. (C) 2011 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/24465http://dx.doi.org/10.1016/j.ejpb.2011.04.012
ISSN
0939-6411
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약학대학 > 약학부 > Articles
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