Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function
- Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function
- 정대원; 이경희; 김현수; 김진만; 김재룡; 김극준[김극준]; 김용진; 박세일; 정재호[정재호]; 문영미[문영미]; 임현숙[임현숙]; 배동원[배동원]; 권조셉[권조셉]; 고창용[고창용]; 김한성[김한성]; 신홍인[신홍인]
- HEPATOCYTE GROWTH-FACTOR; MARROW STROMAL CELLS; KAPPA-B; 1,25-DIHYDROXYVITAMIN D-3; IN-VITRO; DIFFERENTIATION; TISSUE; BIOLOGY; MATRIX; MINERALIZATION
- Issue Date
- JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v.15, no.10, pp.2082 - 2094
- Systemic transplantation of adipose-derived stem cells (ASCs) is emerging as a novel therapeutic option for functional recovery of diverse damaged tissues. This study investigated the effects of systemic transplantation of human ASCs (hASCs) on bone repair. We found that hASCs secrete various bone cell-activating factors, including hepatocyte growth factor and extracellular matrix proteins. Systemic transplantation of hASCs into ovariectomized mice induced an increased number of both osteoblasts and osteoclasts in bone tissue and thereby prevented bone loss. We also observed that conditioned medium from hASCs is capable of stimulating proliferation and differentiation of osteoblasts via Smad/extracellular signal-regulated kinase (ERK)/JNK (c-jun NH(2)-terminal kinase) activation as well as survival and differentiation of osteoclasts via ERK/JNK/p38 activation in vitro. Overall, our findings suggest that paracrine factors secreted from hASCs improve bone repair and that hASCs can be a valuable tool for use in osteoporosis therapy.
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