Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function

Title
Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function
Author(s)
정대원이경희김현수김진만김재룡김극준[김극준]김용진박세일정재호[정재호]문영미[문영미]임현숙[임현숙]배동원[배동원]권조셉[권조셉]고창용[고창용]김한성[김한성]신홍인[신홍인]
Keywords
HEPATOCYTE GROWTH-FACTOR; MARROW STROMAL CELLS; KAPPA-B; 1,25-DIHYDROXYVITAMIN D-3; IN-VITRO; DIFFERENTIATION; TISSUE; BIOLOGY; MATRIX; MINERALIZATION
Issue Date
201110
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v.15, no.10, pp.2082 - 2094
Abstract
Systemic transplantation of adipose-derived stem cells (ASCs) is emerging as a novel therapeutic option for functional recovery of diverse damaged tissues. This study investigated the effects of systemic transplantation of human ASCs (hASCs) on bone repair. We found that hASCs secrete various bone cell-activating factors, including hepatocyte growth factor and extracellular matrix proteins. Systemic transplantation of hASCs into ovariectomized mice induced an increased number of both osteoblasts and osteoclasts in bone tissue and thereby prevented bone loss. We also observed that conditioned medium from hASCs is capable of stimulating proliferation and differentiation of osteoblasts via Smad/extracellular signal-regulated kinase (ERK)/JNK (c-jun NH(2)-terminal kinase) activation as well as survival and differentiation of osteoclasts via ERK/JNK/p38 activation in vitro. Overall, our findings suggest that paracrine factors secreted from hASCs improve bone repair and that hASCs can be a valuable tool for use in osteoporosis therapy.
URI
http://hdl.handle.net/YU.REPOSITORY/24456http://dx.doi.org/10.1111/j.1582-4934.2010.01230.x
ISSN
1582-1838
Appears in Collections:
의과대학 > 미생물학교실 > Articles
의과대학 > 생화학.분자생물학교실 > Articles
의과대학 > 병리학교실 > Articles
의과대학 > 정형외과학교실 > Articles
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