Synthesis, Characterization and Antimicrobial Activity of New Pyrrole Derivatives

Title
Synthesis, Characterization and Antimicrobial Activity of New Pyrrole Derivatives
Author(s)
아크베르이드하야둘라Abdul Jamal Abdul Nasser[Abdul Jamal Abdul Nasser]Radhakrishnan Surendra Kumar[Radhakrishnan Surendra Kumar]
Keywords
PART 1
Issue Date
201110
Publisher
SOC QUIMICA MEXICO
Citation
JOURNAL OF THE MEXICAN CHEMICAL SOCIETY, v.55, no.4, pp.218 - 223
Abstract
Here we describe pyrrole derivatives with potent antibacterial and antifungal activity. A new series of pyrrole 3a-e derivatives were synthesized using standard amination reactions. All the compounds presented here were obtained with high yields and under easy experimental conditions. Synthesized compounds were characterized by IR, H-1 NMR, C-13 NMR, mass spectra and mass spectral fragmentation. Synthesized compounds were screened against E. coli and S. aureus for antibacterial activity, as well as against A. niger and C. albicans for antifungal activity. We were able to obtain compounds with higher or equal potency to the reference compounds (Ciprofloxacin and Clotrimazole). Our data shows that a 4-hydroxyphenyl ring in our most potent compound seems to be responsible for antifungal activity against C. albicans. Incorporation of a 4-hydroxyphenyl ring as a pharmacophoric feature against C. albicans is a promising prospect.
URI
http://hdl.handle.net/YU.REPOSITORY/24448
ISSN
1870-249X
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공과대학 > 화학공학부 > Articles
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