Synthesis of 2,4,6-Tripyridyl Pyridines, and Evaluation of Their Antitumor Cytotoxicity, Topoisomerase I and II Inhibitory Activity, and Structure-activity Relationship

Title
Synthesis of 2,4,6-Tripyridyl Pyridines, and Evaluation of Their Antitumor Cytotoxicity, Topoisomerase I and II Inhibitory Activity, and Structure-activity Relationship
Author(s)
정병선최호영[최호영]곽영신[곽영신]이응석
Keywords
KINASE-C INHIBITORS; 2,4,6-TRISUBSTITUTED PYRIDINE; TERPYRIDINE COMPLEXES; DNA TOPOISOMERASES; DERIVATIVES; INTERCALATION; MOIETY; CELLS
Issue Date
201110
Publisher
KOREAN CHEMICAL SOC
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.32, no.10, pp.3566 - 3570
Abstract
A series of 2,4,6-tripyridyl pyridines were synthesized, and evaluated for their antitumor cytotoxicity, topoisomerase I and II inhibitory activity. From the eighteen prepared compounds, compounds 10-12 have shown better or similar cytotoxicity against several human cancer cell lines as compared to 2,2:6,2 ''-terpyridine and doxorubicin. Especially, compound 10 exhibited the most potent cytotoxicity better than positive controls. Structure-activity relationship study indicated that 2,2':6',2 ''-terpyridine skeleton has an important role in displaying significant cytotoxicity against several human cancer cell lines.
URI
http://hdl.handle.net/YU.REPOSITORY/24417http://dx.doi.org/10.5012/bkcs.2011.32.10.3566
ISSN
0253-2964
Appears in Collections:
약학대학 > 약학부 > Articles
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