Low concentrations of honey reduce biofilm formation, quorum sensing, and virulence in Escherichia coli O157:H7
- Low concentrations of honey reduce biofilm formation, quorum sensing, and virulence in Escherichia coli O157:H7
- 이진태; 김정애; 조무환; 이진형; 이창수[이창수]; 박주현[박주현]; 거네스퍼러사더네오파네
- PSEUDOMONAS-AERUGINOSA VIRULENCE; HEMOLYTIC-UREMIC SYNDROME; GENE-EXPRESSION; INHIBITION; RESISTANCE; O157-H7; AUTOINDUCER-2; BACTERIA; ACID; COMMUNITIES
- Issue Date
- TAYLOR & FRANCIS LTD
- BIOFOULING, v.27, no.10, pp.1095 - 1104
- Bacterial biofilms are associated with persistent infections due to their high resistance to antimicrobial agents. Hence, controlling pathogenic biofilm formation is important in bacteria-related diseases. Honey, at a low concentration of 0.5% (v/v), significantly reduced biofilm formation in enterohemorrhagic Escherichia coli O157:H7 without inhibiting the growth of planktonic cells. Conversely, this concentration did not inhibit commensal E. coli K-12 biofilm formation. Transcriptome analyses showed that honey significantly repressed curli genes (csgBAC), quorum sensing genes (AI-2 importer and indole biosynthesis), and virulence genes (LEE genes). Glucose and fructose in the honeys were found to be key components in reducing biofilm formation by E. coli O157:H7 through the suppression of curli production and AI-2 import. Furthermore, honey, glucose and fructose decreased the colonization of E. coli O157:H7 cells on human HT-29 epithelial cells. These results suggest that low concentrations of honey, such as in honeyed water, can be a practical means for reducing the colonization and virulence of pathogenic E. coli O157:H7.
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