Immunostimulatory effect by aqueous extract of Hizikia fusiforme in RAW 264.7 macrophage and whole spleen cells

Title
Immunostimulatory effect by aqueous extract of Hizikia fusiforme in RAW 264.7 macrophage and whole spleen cells
Author(s)
나민균윤여대[윤여대]이은숙[이은숙]박종필[박종필]김미리[김미리]이준원[이준원]김태훈김진희[김진희]
Keywords
ACANTHOPANAX-OBOVATUS ROOTS; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE; PLATYCODON-GRANDIFLORUM; POLYSACCHARIDE; FUCOIDAN; ACTIVATION; EXPRESSION; INDUCTION; SEAWEED
Issue Date
201111
Publisher
KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
Citation
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.16, no.6, pp.1099 - 1105
Abstract
Hizikia fusiforme is a commonly used food that possesses potent anti-bacterial, anti-fungal, and anti-inflammatory activities. The immunostimulatory activities of aqueous extract of Hizikia fusiforme (HFAE) in RAW 264.7 macrophages and whole spleen cells were investigated. HFAE activated RAW 264.7 macrophages to produce cytokines such as nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6) in a dose-dependent manner. In addition, HFAE induced the mRNA expression of TNF-alpha, IL-1 beta, and IL-6 in RAW 264.7 macrophages. Moreover, HFAE stimulated proliferation of whole spleen cells and reference mitogen. Taken together, the results demonstrate that HFAE potently activates the immune function by regulating NO, TNF-alpha, IL-1 beta, and IL-6 in RAW 264.7 macrophage and promoting spleen cell proliferation.
URI
http://hdl.handle.net/YU.REPOSITORY/24281http://dx.doi.org/10.1007/s12257-011-0177-5
ISSN
1226-8372
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약학대학 > 약학부 > Articles
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