Manassantin A Isolated from Saururus chinensis Inhibits 5-Lipoxygenase-Dependent Leukotriene C-4 Generation by Blocking Mitogen-Activated Protein Kinase Activation in Mast Cells

Title
Manassantin A Isolated from Saururus chinensis Inhibits 5-Lipoxygenase-Dependent Leukotriene C-4 Generation by Blocking Mitogen-Activated Protein Kinase Activation in Mast Cells
Author(s)
장현욱김수정[김수정]유예[유예]권오균[권오균]황보 경[황보 경]서창섭[서창섭]이승호김철호[김철호]장영채[장영채]손종근
Issue Date
201111
Publisher
PHARMACEUTICAL SOC JAPAN
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.34, no.11, pp.1769 - 1772
Abstract
In this study, manassantin A (Man A), an herbal medicine isolated from Saururus chinensis (S. chinensis), markedly inhibited 5-lipoxygenase (5-LO)-dependent leukotriene C-4 (LTC4) generation in bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner. To investigate the molecular mechanisms underlying the inhibition of LTC4 generation by Man A, we assessed the effects of Man A on phosphorylation of cytosolic phospholipase A(2) (cPLA(2)) and mitogen-activated protein kinases (MAPKs). Inhibition of LTC4 generation by Man A was accompanied by a decrease in cPLA(2) phosphorylation, which occurred via the MAPKs including extracellular signal-regulated protein kinase-1/2 (ERK1/2) as well as p38 and c-Jun N-terminal kinase (JNK) pathways. Taken together, the present study suggests the Man A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases.
URI
http://hdl.handle.net/YU.REPOSITORY/24278
ISSN
0918-6158
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약학대학 > 약학부 > Articles
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