Effect of tamsulosin on ejaculatory function in BPH/LUTS

Title
Effect of tamsulosin on ejaculatory function in BPH/LUTS
Author(s)
문기학송상훈[송상훈]손환철[손환철]김광택[김광택]김세웅[김세웅]문두건[문두건]박광성[박광성]박종관[박종관]이성원[이성원]현재석[현재석]박남철[박남철]
Keywords
BENIGN PROSTATIC HYPERPLASIA; URINARY-TRACT SYMPTOMS; PHASE-III MULTICENTER; ALPHA-1-ADRENOCEPTOR ANTAGONISTS; PREMATURE EJACULATION; SEXUAL FUNCTION; PREVALENCE; BPH; COMMUNITY; MEN
Issue Date
201111
Publisher
ACTA PHARMACOLOGICA SINICA
Citation
ASIAN JOURNAL OF ANDROLOGY, v.13, no.6, pp.846 - 850
Abstract
This study was undertaken to determine the impact on ejaculatory function of tamsulosin (0.2 mg) given once daily (OD) for 12 weeks and to identify risk factors for ejaculatory dysfunction in patients undergoing this treatment. Males with an International Prostatic Symptom Score (IPSS) >= 8 were enrolled in this study. All participants completed questionnaires, including the IPSS and the Male Sexual Health Questionnaire (MSHQ), and serum prostate-specific antigen, transrectal ultrasound and uroflowmetry with post-void residual were measured. After initiating 0.2 mg OD tamsulosin, patients were re-evaluated on the fourth and twelfth weeks of medication. The chi-squared test, the independent t-test and one-way ANOVA were used to compare means. Binary logistic regression analysis was used to calculate the odds ratio for all risk factors. A total of 177 men constituted the study cohort. No significant difference was observed between baseline and follow-up for the erectile function, ejaculatory function, satisfaction, sexual activity and desire domains (EFD, EjFD, SDA and ADD) or for erectile or ejaculatory bother mean scores. After 12 weeks, the overall incidence of ejaculatory dysfunction (EjD) was 13.4%. Incidences of the seven different types of EjD (decreased frequency, delay, dryness, decreased strength/force, decreased volume, decreased pleasure and pain at ejaculation) were 2.4%, 3.1%, 3.9%, 3.9%, 6.3%, 7.1% and 3.1%, respectively. Baseline EjFD scores were higher for IPSS responders than for non-responders (26.09 vs. 24.06, P=0.03). An EjFD score reduction was more frequent in IPSS responders. The incidence of EjD was small, but not negligible and was more frequent in patients with less lower urinary tract symptoms, a smaller prostate, higher baseline MSHQ totals and higher EjFD scores. Asian Journal of Andrology (2011) 13, 846-850; doi: 10.1038/aja.2011.25; published online 25 July 2011
URI
http://hdl.handle.net/YU.REPOSITORY/24271http://dx.doi.org/10.1038/aja.2011.25
ISSN
1008-682X
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의과대학 > 비뇨기과학교실 > Articles
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