Ergosta-7,22-diene-2 beta,3 alpha,9 alpha-triol from the Fruit Bodies of Ganoderma lucidum Induces Apoptosis in Human Myelocytic HL-60 Cells

Title
Ergosta-7,22-diene-2 beta,3 alpha,9 alpha-triol from the Fruit Bodies of Ganoderma lucidum Induces Apoptosis in Human Myelocytic HL-60 Cells
Author(s)
이미경[이미경]Tran Manh Hung[Tran Manh Hung]To Dao Cuong[To Dao Cuong]나민균김진철[김진철]김은정[김은정]박희성[박희성]최재수[최재수]이익수[이익수]배기환[배기환]Masao Hattori[Masao Hattori]민병선[민병선]
Keywords
LEWIS LUNG-CARCINOMA; ADIPOCYTE DIFFERENTIATION; LANOSTANE TRITERPENES; 3T3-L1 CELLS; ACTIVATION; EXTRACT; DISEASE; GROWTH; CANCER; ASSAY
Issue Date
201111
Publisher
WILEY-BLACKWELL
Citation
PHYTOTHERAPY RESEARCH, v.25, no.11, pp.1579 - 1585
Abstract
Ganoderma lucidum is known as a medicinal mushroom used in traditional medicine. In our study, the cytotoxic activities of 17 compounds (1-17) isolated from the fruiting bodies of G. lucidum were investigated. Among them, ergosta-7,22-diene-2 beta,3 alpha,9 alpha-triol (EGDT) induced apoptosis in HL-60 human premyelocytic leukemia cells. EGDT activated the apoptotic process, including DNA fragmentation and caspase-3 activity. In immunoblotting analysis, treatment with EGDT resulted in the cleavage of procaspase-3 and poly(ADP-ribose) polymerase (PARP) into active forms. In the in vivo study, the administration (i.p.) of EGDT to Lewis lung carcinoma (LLC)-inoculated mice evidenced a significant inhibition of tumor growth. These results indicate that EGDT was one of the apoptotic constituents of G. lucidum, and might be an antitumor agent. Copyright (C) 2011 John Wiley & Sons, Ltd.
URI
http://hdl.handle.net/YU.REPOSITORY/24268http://dx.doi.org/10.1002/ptr.3447
ISSN
0951-418X
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약학대학 > 약학부 > Articles
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