Inhibitory effect on NO production of phenolic compounds from Myristica fragrans

Title
Inhibitory effect on NO production of phenolic compounds from Myristica fragrans
Author(s)
나민균To Dao Cuong[To Dao Cuong]Tran Manh Hung[Tran Manh Hung]Do Thi Ha[Do Thi Ha]김진철[김진철]이동호[이동호]류승우[류승우]이정형[이정형]최재수[최재수]민병선[민병선]
Keywords
LIGNANS; MACE; IDENTIFICATION; CONSTITUENTS; OIL
Issue Date
201111
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.22, pp.6884 - 6887
Abstract
Three new phenolics: ((7S)-8'-(benzo[3',4']dioxol-1'-yl)-7-hydroxypropyl)benzene-2,4-diol (1), ((7S)-8'- (4'-hydroxy-3'-methoxyphenyl)-7-hydroxypropyl)benzene-2,4-diol (2) and ((8R,8'S)-7-(4-hydroxy-3-methoxyphenyl)-8'-methylbutan-8-yl)-3'-methoxybenzene-4',5'-diol (3), along with four known compounds (4-7) were isolated from the seeds of Myristica fragrans. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/24267http://dx.doi.org/10.1016/j.bmcl.2011.09.021
ISSN
0960-894X
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약학대학 > 약학부 > Articles
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