Down-regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53-dependent pathway

Title
Down-regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53-dependent pathway
Author(s)
김재룡조정희[조정희]김희진[김희진]권혁수[권혁수]
Keywords
REPLICATIVE SENESCENCE; CANCER; P53; POLYPLOIDY; ACTIVATION; INDUCTION; APOPTOSIS
Issue Date
201111
Publisher
ELSEVIER SCIENCE BV
Citation
FEBS LETTERS, v.585, no.22, pp.3569 - 3576
Abstract
Aurora B kinase (Aurora-B) functions in chromosome segregation and cleavage of polar spindle microtubules. However, its role in cellular senescence remains elusive. Here, we investigated Aurora-B effects on cellular senescence in human fibroblasts and endothelial cells. Aurora-B levels were reduced during replicative senescence and premature senescence by adriamycin. Aurora-B overexpression in old cells partially reversed senescence phenotypes. In contrast, Aurora-B down-regulation accelerated cellular senescence. p53 knockdown but not p16 knockdown inhibited cellular senescence by Aurora-B reduction. These results suggest that Aurora-B might function in the regulation of cellular senescence of human primary cells via a p53-dependent pathway. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/24260http://dx.doi.org/10.1016/j.febslet.2011.10.022
ISSN
0014-5793
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
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